5-HImodulation of auditory and visual sensorimotor gating: I. Effectsof 5-HTreleaserson soundand light prepulseinhibition in Wistar rats

Increasing evidence suggests an important effects of fenfluramine could be dissociated. MDL role for serotonin (5-HT) neurons in the etiology and 28,618A alone did not affect prepuise inhibition or basal treatment of schizophrenia. The prepulse inhibition parastartle levels, demonstrating an important functional difdigm is used as a model for sensorimotor gating processference between pharmacologically induced 5-HT uptake i es that are disrupted in schizophrenia. The present study blockade and 5-HT release. In summary, these data indiassessed the general role of 5-HT in modulating auditory cate that serotonergic overactivation can disrupt auditory anti visual prepulse inhibition in Wistar rats. A general and visual sensorimotor gating as measured using sound meractivation of central serotonerigic pathways was proand light prepulse inhibition in rats. These data support a duced pharmacologically by four different agents which potential role of excessive 5-HT activity as a contributall shared the common property of releasing 5-HT, i.e., ing factor to disrupted sensory gating processes seen in /_-chloroamphetamine, 3,4-methylenedioxymethamphetschizophrenia and possibly other neuropsychiatric disoranfine, N-ethyl-3,4-methylenedioxymethamphetamine, ders. or fenfluramine. Within each test session, both sound and light prepulses were used to obtain a cross-modal as